Genitourinary dysfunction in Parkinson's disease
Identifieur interne : 001C66 ( Main/Exploration ); précédent : 001C65; suivant : 001C67Genitourinary dysfunction in Parkinson's disease
Auteurs : Ryuji Sakakibara [Japon] ; Tomoyuki Uchiyama [Japon] ; Tomonori Yamanishi [Japon] ; Masahiko Kishi [Japon]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-01-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Autonomic nervous system, Basal Ganglia (physiopathology), Dopamine, Dysfunction, Erectile Dysfunction (etiology), Erectile Dysfunction (pathology), Erectile Dysfunction (therapy), Female, Humans, Male, Nervous system diseases, Neural Pathways (physiopathology), Parkinson Disease (complications), Parkinson disease, Parkinson's disease, Sexual dysfunction, Urinary Bladder Diseases (etiology), Urinary Bladder Diseases (pathology), Urinary Bladder Diseases (therapy), Urinary bladder, autonomic nervous system, bladder dysfunction, dopamine, sexual dysfunction.
- MESH :
- complications : Parkinson Disease.
- etiology : Erectile Dysfunction, Urinary Bladder Diseases.
- pathology : Erectile Dysfunction, Urinary Bladder Diseases.
- physiopathology : Basal Ganglia, Neural Pathways.
- therapy : Erectile Dysfunction, Urinary Bladder Diseases.
- Female, Humans, Male.
Abstract
Bladder dysfunction (urinary urgency/frequency) and sexual dysfunction (erectile dysfunction) are common nonmotor disorders in Parkinson's disease (PD). In contrast to motor disorders, genitourinary autonomic dysfunctions are often nonresponsive to levodopa treatment. The brain pathology causing the bladder dysfunction (appearance of overactivity) involves an altered dopamine‐basal ganglia circuit, which normally suppresses the micturition reflex. By contrast, hypothalamic dysfunction is mostly responsible for the sexual dysfunction (decrease in libido and erection) in PD, via altered dopamine‐oxytocin pathways, which normally promote libido and erection. The pathophysiology of the genitourinary dysfunction in PD differs from that in multiple system atrophy; therefore, it might aid in differential diagnosis. Anticholinergic agents are used to treat bladder dysfunction in PD, although these drugs should be used with caution particularly in elderly patients who have cognitive decline. Phosphodiesterase inhibitors are used to treat sexual dysfunction in PD. These treatments might be beneficial in maximizing the patients' quality of life. © 2010 Movement Disorder Society
Url:
DOI: 10.1002/mds.22519
Affiliations:
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-01-15">2010-01-15</date><biblScope unit="vol">25</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="2">2</biblScope><biblScope unit="page" to="12">12</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">2522D61E7D3D87A8EA987AA52B3D96C2E1E2DA73</idno><idno type="DOI">10.1002/mds.22519</idno><idno type="ArticleID">MDS22519</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Autonomic nervous system</term><term>Basal Ganglia (physiopathology)</term><term>Dopamine</term><term>Dysfunction</term><term>Erectile Dysfunction (etiology)</term><term>Erectile Dysfunction (pathology)</term><term>Erectile Dysfunction (therapy)</term><term>Female</term><term>Humans</term><term>Male</term><term>Nervous system diseases</term><term>Neural Pathways (physiopathology)</term><term>Parkinson Disease (complications)</term><term>Parkinson disease</term><term>Parkinson's disease</term><term>Sexual dysfunction</term><term>Urinary Bladder Diseases (etiology)</term><term>Urinary Bladder Diseases (pathology)</term><term>Urinary Bladder Diseases (therapy)</term><term>Urinary bladder</term><term>autonomic nervous system</term><term>bladder dysfunction</term><term>dopamine</term><term>sexual dysfunction</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Erectile Dysfunction</term><term>Urinary Bladder Diseases</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Erectile Dysfunction</term><term>Urinary Bladder Diseases</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Basal Ganglia</term><term>Neural Pathways</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Erectile Dysfunction</term><term>Urinary Bladder Diseases</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Female</term><term>Humans</term><term>Male</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Dopamine</term><term>Dysfonctionnement sexuel</term><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Système nerveux autonome</term><term>Trouble fonctionnel</term><term>Vessie urinaire</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Bladder dysfunction (urinary urgency/frequency) and sexual dysfunction (erectile dysfunction) are common nonmotor disorders in Parkinson's disease (PD). In contrast to motor disorders, genitourinary autonomic dysfunctions are often nonresponsive to levodopa treatment. The brain pathology causing the bladder dysfunction (appearance of overactivity) involves an altered dopamine‐basal ganglia circuit, which normally suppresses the micturition reflex. By contrast, hypothalamic dysfunction is mostly responsible for the sexual dysfunction (decrease in libido and erection) in PD, via altered dopamine‐oxytocin pathways, which normally promote libido and erection. The pathophysiology of the genitourinary dysfunction in PD differs from that in multiple system atrophy; therefore, it might aid in differential diagnosis. Anticholinergic agents are used to treat bladder dysfunction in PD, although these drugs should be used with caution particularly in elderly patients who have cognitive decline. Phosphodiesterase inhibitors are used to treat sexual dysfunction in PD. These treatments might be beneficial in maximizing the patients' quality of life. © 2010 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Japon</li></country></list><tree><country name="Japon"><noRegion><name sortKey="Sakakibara, Ryuji" sort="Sakakibara, Ryuji" uniqKey="Sakakibara R" first="Ryuji" last="Sakakibara">Ryuji Sakakibara</name></noRegion><name sortKey="Kishi, Masahiko" sort="Kishi, Masahiko" uniqKey="Kishi M" first="Masahiko" last="Kishi">Masahiko Kishi</name><name sortKey="Sakakibara, Ryuji" sort="Sakakibara, Ryuji" uniqKey="Sakakibara R" first="Ryuji" last="Sakakibara">Ryuji Sakakibara</name><name sortKey="Uchiyama, Tomoyuki" sort="Uchiyama, Tomoyuki" uniqKey="Uchiyama T" first="Tomoyuki" last="Uchiyama">Tomoyuki Uchiyama</name><name sortKey="Yamanishi, Tomonori" sort="Yamanishi, Tomonori" uniqKey="Yamanishi T" first="Tomonori" last="Yamanishi">Tomonori Yamanishi</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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